TABLE 6.

Activities of NPC1161A, NPC1161B, and NPC1161C against Leishmania donovani infection in mice

CompoundDose (mg/kg/day)a% Inhibition of parasites in liver
NPC1161A100b
NPC1161B10099.8
NPC1161C10099.0c
NPC1161A10.099.58 ± 0.54
NPC1161B10.099.29 ± 0.83
NPC1161C10.099.76 ± 0.16
NPC1161A5.064.98 ± 8.49
NPC1161B5.098.0 ± 0.81
NPC1161C5.099.24 ± 0.47
NPC1161A0.441.17 ± 8.0
NPC1161B0.461.49 ± 8.46
NPC1161C0.434.09 ± 9.01
Sodium stibogluconate4599.29 ± 0.35
1559.4 ± 15.3
513.83 ± 4.64
  • a Doses for the control treatment, sodium stibogluconate, are expressed in terms of pentavalent antimony (SbV).

  • b All mice died at the end of the treatment period prior to evaluation.

  • c Two/five mice died at the end of the treatment period prior to evaluation.