TABLE 2.

Comparison of parameter estimates and objective function values from competing absorption modelsa

Absorption modelΔOFV (df)CL/F (IIV) (liters h−1)V/F (IIV) (liters)ka (IIV) (liters h−1)εadd (mg liter−1)εccv
First order0 (0)19.4 (0.321)52.8 (0.427)1.61 (2.39)0.2560.302
First order and lag time−83.026 (1)20.2 (0.387)53.4 (0.415)1.64 (0.689)0.4090.255
Sequential 0 order and first order−270.703 (2)19.2 (0.314)51.5 (0.384)1.23 (0.787)0.2540.259
Transit compartment−391.939 (3)19.2 (0.279)53.2 (0.188)1.15 (0.439)0.09230.222
  • a ΔOFV = change in NONMEM objective function value; df = degrees of freedom; CL/F = apparent clearance; V/F = apparent volume of distribution; ka = absorption rate constant; εadd = additive residual error; εccv = proportional residual error; IIV = interindividual variability (variance).