TABLE 1.

Suppressive antimalarial activities of NPC1161C, tafenoquine, and primaquine against P. berghei in mice

CompoundDose (mg/kg/day)Total dose (mg/kg)ΔMSTa (days)No. of mice alive at day +60/total no. of mice
NPC1161C641927/7
16487/7
4127/7
137/7
Tafenoquine6419214.51/7
16487/7
4129.71/7
136.60/7
Primaquine641929.53/7
16489.31/7
4123.80/7
1300/7
Control0000/7
  • a ΔMST, increase in mean survival time over that of the controls (8.4 days).