TABLE 5.

Oral prophylactic efficacies of NPC1161A, NPC1161B, and racemate against pneumocystis infection in mice

CompoundDose (mg/kg/day; for 21 days)Result with stain:
GiemsaSilver
I/TaScoreI/TaScore
NPC1161A0.250/100.00/100.0
NPC1161B0.250/100.00/100.0
NPC1161C0.250/100.00/100.0
NPC1161A0.14/100.3 ± 0.13/100.1 ± 0.0
NPC1161B0.10/100.01/100.03 ± 0.02
NPC1161C0.11/100.1 ± 0.10/100.0
Primaquine2.010/104.3 ± 0.110/102.8 ± 0.1
TMP-SMX50/2501/100.03 ± 0.020/100.0
Control10/104.3 ± 0.110/103.4 ± 0.1
  • a I/T, number of animals with organism after treatment/number of animals treated.