TABLE 3.

Duration of protection by NPC1161A and NPC1161B against P. berghei infection in mice

Day of treatment with compoundaΔMSTb (days)No. of mice alive at day +30/total no. of mice
−3
    NPC1161A0.00/5
    NPC1161B4.60/5
−2
    NPC1161A0.00/5
    NPC1161B8.43/5
−1
    NPC1161A0.60/5
    NPC1161B5/5
0
    NPC1161A3.40/5
    NPC1161B5/5
+1
    NPC1161A0.00/5
    NPC1161B5/5
+2
    NPC1161A1.20/5
    NPC1161B5/5
Control0.00/5
  • a A single dose of 2 mg/kg was administered on the day indicated. Controls received no treatment.

  • b ΔMST, increase in mean survival time over that of the controls (10.6 days).