TABLE 1.

MFX PK data

ParameteraPlasmaCSF
400 mg800 mg400 mg800 mg
AUC0-24 (mg · h/liter)8.919.48.414.3
Free AUC0-24b (mg · h/liter)5.311.68.414.3
Cmax (mg/liter)1.062.450.6161.42
Tmaxb (h)2244
Cmin (mg/liter)0.070.050.030.06
t1/2 (h)4.554.095.525.20
CL/F71.3432.381.146.0
AUC0-24/MIC ratio59.3129.356.095.3
Free AUC0-24/MIC ratio35.377.356.095.3
  • a Abbreviations: Cmax, maximum concentration of drug in plasma or CSF; Tmax, time to maximum concentration of drug in serum; Cmin, minimum concentration of drug in plasma or CSF; t½, half-life; CL/F, apparent total body clearance.

  • b Calculated with a protein binding of 40%.