TABLE 4.

Oral efficacies of NPC1161A, NPC1161B, and racemate against pneumocystis infection in mice

CompoundNominal dose (mg/kg/day; for 21 days)Result with stain:
GiemsaSilver
I/TaScoreI/TaScore
NPC1161A50/100.00/100.0
NPC1161B50/100.00/100.0
NPC1161C1.30/100.00/100.0
NPC1161A10/100.00/100.0
NPC1161B10/100.00/100.0
NPC1161A0.52/100.20 ± 0.102/100.1 ± 0.1
NPC1161B0.50/100.00/100.0
NPC1161A0.254/100.55 + 0.169/101.15 ± 0.16
NPC1161B0.250/100.00/100.0
TMP-SMX50/2501/100.03 ± 0.020/100.0
Control10/104.43 ± 0.1210/103.80 ± 0.08
  • a I/T, number of animals with organism after treatment/number of animals treated.