TABLE 7.

Comparison of antileishmanial activities of NPC1161B and sitamaquine against Leishmania donovani infection in mice

CompoundDose (mg/kg/day)a% Inhibition (±95% CLb)ED50 (mg/kg) (95% CL)cED90 (mg/kg) (95% CL)d
NPC1161B5.097.6 (1.35)1.28 (0.92-1.77)3.61 (1.28-10.19)
1.036.0 (19.81)
0.26.5 (14.43)
Sitamaquine5.095.56 (1.35)1.55 (1.12-2.15)4.14 (1.86-9.19)
1.025.76 (13.25)
0.215.62 (7.47)
Sodium stibogluconate45.067.05 (12.64)27.7 (20.7-37.3)>45
15.029.32 (19.47)
5.00
  • a Doses for the control treatment, sodium stibogluconate, are expressed in terms of pentavalent antimony (SbV).

  • b CL, confidence limit.

  • c Confidence limits derived in MS Excel.

  • d Confidence limits derived in Prism.