TABLE 4.

Comparison of model estimates of AUC with reported values from the literaturea

Source or referencePopulationDosingnbParameterAUC value in mg h−1 liter−1
Current studySouth African PTB patients at steady stateOral, adjusted for body wt; 450/480 mg for ≤50 kg, 600 mg for over 50 kg261AUC0-24 (steady-state model prediction)30.7 (SD = 13.2)
9Kenyan PTB patients without HIV at steady stateOral, adjusted for body wt; 450 mg for ≤45kg, 600 mg for over 45kg15AUC0-12 (linear trapezoidal)23.1 (SD = 12.9)
9Kenyan PTB patients with HIV at steady stateOral, adjusted for body wt; 450 mg for ≤45 kg, 600 mg for over 45 kg14AUC0-12 (linear trapezoidal)19.6 (SD = 10.6)
16Indian PTB patients without HIV at steady state (mean wt 43 kg; range, 32-65 kg)Oral, 450 mg13AUC0-∞ (linear trapezoidal)44.6 (range, 36.3-52.9)
16Indian PTB patients with HIV at steady state (mean wt 42 kg; range, 23-62 kg)Oral, 450 mg15AUC0-∞ (linear trapezoidal)28.2 (range, 18.1-38.4)
31German PTB patients at steady state (mean wt 67 kg; range, 50-82 kg)Oral, 600 mg6AUC0-12 (linear trapezoidal)60.3 (SD = 33.4)
51North American PTB patients with HIV at steady stateOral, adjusted for body wt; 450 mg for ≤50 kg, 600 mg for over 50 kg31AUC0-10 (3-point linear trapezoidal)30.1 (CV = 48.1%)
57Indonesian PTB patients at steady state (mean wt 48.4 ± 6.9 kg)Oral, 450 mg24AUC0-24 (linear trapezoidal)48.5 (26.7-72.8)
57Indonesian PTB patients at steady state (mean wt 47.3 ± 8.1 kg)Oral, 600 mg23AUC0-24 (linear trapezoidal)79.7 (38.7-138.1)
63Botswanan PTB patients without HIV at steady stateOral, adjusted for body wt; 450 mg for ≤50 kg, 600 mg for over 50 kg20AUC0-12 (extrapolated linear trapezoidal)34.7 (range, 15.5-77.4)
63Botswanan PTB patients with HIV at steady stateOral, adjusted for body wt; 450 mg for ≤50 kg, 600 mg for over 50 kg41AUC0-12 (extrapolated linear trapezoidal)36.3 (range, 10.8-95.0)
  • a PTB, pulmonary tuberculosis.

  • b n, number of samples.