TABLE 2.

Suppressive antimalarial activities of NPC1161A, NPC1161B, and NPC1161C against P. berghei in mice

CompoundDose (mg/kg/day)Total dose (mg/kg)ΔMSTa (days)No. of mice alive at day +34/total no. of miceParasitemia (%) on day +6
NPC1161A412110/51.1
1360/527.4
0.250.7500/528.2
NPC1161B4125/50.0
1320.52/50.0
0.250.7511.60/50.2
NPC1161C1310.20/50.1
0.250.7511.60/54.8
Control0000/531.8
  • a ΔMST, increase in mean survival time over that of the controls (8.4 days).