TABLE 3.

Mean pharmacokinetic parameters of tigecycline after various i.v. doses infused over a 1-h period q12h in the MAD study

Tigecycline dose group (mg)Mean Value (%CV) at:
Day 1Day 10a
Cmax (ng/ml)AUC0-τ (ng h/ml)Cmax (ng/ml)AUCss (ng h/ml)t1/2 (h)CL (l/h/kg)Vss (l/kg)
25261 (14)796 (8)324 (17)1,482 (18)49.3 (72)0.20 (17)8.6 (23)
50487 (17)1,440 (14)621 (15)3,069 (12)36.9 (32)0.20 (9)7.2 (7)
100816 (15)2,389 (13)1,173 (15)4,980 (19)66.5 (34)0.24 (20)9.1 (32)
  • a Day 10 values for the 100-mg tigecycline dose group are actually day 9 values.