TABLE 3.

Antibacterial activity of WLBU2 is not strain specifica

P. aeruginosa strainMBC (μM)
WLBU2LL37
PA12440.32
PACO1*0.52
PACO3*0.31
PACO40.52
PACO60.52
PACO7*0.52
PACO80.31
PACO90.31
PACO100.32
PACO110.52
PACO120.52
PACO13*0.52
PACO140.32
ATCC 19142*0.35
ATCC 33468*0.32
PAO10.51
  • a To investigate whether the potent activity displayed by WLBU2 was dependent on the specificity of the clinical strains, we performed standard bacterial killing assays (in PBS) with a panel of 16 strains of P. aeruginosa, 6 of which were of mucoid phenotype. The peptide not only maintained its potent effects against all of these strains but also demonstrated a 4- to 13-fold-higher bactericidal activity than that of LL37. The data tabulated are representative of two experimental trials. *, Mucoid type.