TABLE 4.

Effects of BM0 sequence modifications on antifungal activity against S. cerevisiae

Name of peptideSequenceaMIC/MFCb (μM) at pH 7.3
BM0d-NH2-RFWWFRRR-CONH20.625s/2.5c
BM1d-NH2-RRFWWFRRR-CONH20.625s/1.25c
BM2d-NH2-RRRFWWFRRR-CONH20.625c
BM3d-NH2-RWWWFRRR-CONH20.625s/2.5c
BM4d-NH2-RFFWFRRR-CONH20.625s/2.5c
BM5d-NH2-RFLWFRRR-CONH20.625c/2.5c
BM6d-NH2-RFWFFRRR-CONH21.25c
BM7d-NH2-RFWNFRRR-CONH21.25c
BM8d-NH2-RFWKFRRR-CONH20.625s/5c
BM9d-NH2-RFWRFRRR-CONH21.25c
BM47d-NH2-RFWWARRR-CONH20.625s/2.5c
  • a Amino acid residues that differ from those in BM0 are given in boldface.

  • b s, fungistatic; c, fungicidal.