TABLE 3.

Effects of stereochemistry and structure on BM0 antifungal activity

PeptideMIC90 (μM)aIC50 (μM) for S. cerevisiae Pma1p (7.0)
S. cerevisiae (7.3)bC. albicans (7.5)C. glabrata (7.5)C. tropicalis (7.5)
d-NH2-RFWWFRRR-CONH2 (BMO)0.467.37.37.32.6
d-NH2-RRRFWWFR-CONH21.66.33.16.31.8
l-NH2-RFWWFRRR-CONH21.931157.73.8
l-NH2-RRRFWWFR-CONH22.0168.04.02.2
d-NH2-RFWWF-CONH21188444417
d-CH3CO-RFWWFRRR-CONH22.08.08.08.05.8
  • a MIC90, minimum concentration at which there is >90% growth inhibition compared to no-peptide control.

  • b Values in parentheses are pHs.