TABLE 4.

Trough concentrations of tigecycline among various dose groups after multiple doses of tigecycline given as a 1-h infusion in the MAD study

DayMean (% cv) concn (ng/ml)a at:P
25 mg50 mg100 mg
786 (28)153 (13)214 (13)0.07
881 (34)195 (15)255 (16)0.12
983 (28)204 (17)257 (17)0.06
1087 (26)145 (16)NA0.23
  • a For comparison among dose groups, concentrations were dose normalized to the 100-mg dose before statistical analysis. For the 25-, 50-, and 100-mg dose groups, the P values were 0.98, 0.01, and 0.37, respectively. NA, not available.