TABLE 2.

Relationship between length and helical contenta

PeptideLength (no. of residues)% Helicity
LBU11227
LBU22482
LBU33680
LBU44892
WLBU11225
WLBU22481
WLBU33692
WLBU44875
LBU1.31542
LBU1.61845
LBU1.92182
  • a To evaluate the relationship between length and helical content, the percent helicity was obtained from the CD data by using the program K2D over the internet (www.embl-heidelberg.de/≈andrade/k2d/) (3). Although the length seems to correlate with helicity, there is little increase in helical content in peptides longer than 24 residues. These data, together with the results of the bacterial killing assays, reveal a similar correlation between helicity and antibacterial activity in PB. The data tabulated are representative of two to three experimental trials.