TABLE 2.

Pharmacokinetic parameters of tomopenem following single-dose administration of 1,500 mg of tomopenem to subjects with various degrees of renal functiona

GroupbCmax (μg/ml)Tmax (h)t1/2 (h)AUC (μg·h/ml)Vss (liters)CL (liters/h)
A (normal)81.4 ± 16.91.00 (0.95-1.03)2.23 ± 0.23191 ± 35.218.8 ± 3.58.07 ± 1.41
B (mild)106 ± 11.21.00 (0.98-1.00)3.00 ± 0.73304 ± 54.516.2 ± 2.05.08 ± 0.91
C (moderate)100 ± 14.41.00 (1.00-1.68)4.59 ± 1.13517 ± 14617.2 ± 2.73.06 ± 0.67
D (severe)116 ± 38.91.02 (1.00-3.02)7.94 ± 1.231,037 ± 23816.4 ± 5.01.52 ± 0.35
  • a Data are means ± standard deviations (SD), except for values for Tmax, which are median (range) values.

  • b Each group included eight subjects.