TABLE 2.

Kill kinetics of telavancin and comparators against resistant gram-positive isolates

OrganismbAntibioticMIC (μg/ml)Concentration tested (μg/ml)Change in log10 CFU/ml at indicated time (h)a
24824
S. aureusTelavancin0.51−0.7−1.3−3.4c−2.1
2−0.6−1.63.13.4
4−0.7−1.73.43.4
Vancomycin18−0.4−2.23.43.4
Linezolid216−0.3−0.8−2.33.4
S. aureusTelavancin0.51−0.9−1.8−3.2−2.7
2−1.0−2.8−2.7−2.8
4−1.2−1.8−3.03.3
Vancomycin0.54−0.7−1.6−2.93.3
Linezolid216−0.20.03−0.7−3.1
S. epidermidisTelavancin12−1.0−1.8−3.23.3
4−0.5−2.73.33.3
8−0.5−3.23.33.3
Vancomycin216−0.2−1.4−3.3−2.4
Linezolid216−1.2−1.1−1.4−2.3
S. pneumoniaeTelavancin0.0150.03−1.1−2.73.43.4
0.06−1.0−2.13.43.4
0.12−1.1−1.9−3.33.4
Vancomycin0.252−1.8−3.03.43.4
Linezolid18−1.2−1.7−2.63.4
S. agalactiaeTelavancin0.060.12−1.0−0.8−2.3−0.6
0.25−1.0−0.9−1.63.6
0.5−0.87−1.0−1.63.6
Vancomycin0.252−0.8−0.8−1.0−2.7
Linezolid18−1.1−0.9−1.83.7
S. pyogenesTelavancin0.060.12−0.4−0.4−0.52.2
0.25−0.7−1.8−2.5−2.2
0.5−0.9−1.6−2.33.1
Vancomycin0.252−1.8−2.73.13.1
Linezolid18−0.6−1.2−2.7−2.7
E. faecalisTelavancin12−0.5−0.5−0.6−0.8
4−0.5−0.5−0.7−1.2
8−0.5−0.5−0.7−1.1
Linezolid18−0.2−0.2−0.5−1.0
  • a Data represent mean values obtained from three independent experiments.

  • b S. aureus, MED 2028 (top) and MED 1805 (bottom); S. epidermidis, ATCC 35984; S. pneumoniae, MED 1090; S. agalactiae, MED 2038; S. pyogenes, MED 2040; E. faecalis, ATCC 51575.

  • c Bold type indicates plate counts that reached the lower limit of quantitation.