TABLE 3.

Plasma pharmacokinetic parameters of the metabolite, RO4957463, and AUC ratios of metabolite to parent following single-dose administration of 1,500 mg of tomopenem to subjects with various degrees of renal functiona

GroupbCmax (μg/ml)Tmax (h)t1/2 (h)AUC(μg·h/ml)AUCM/P
A3.51 ± 0.811.01 (1.00-1.50)2.98 ± 0.3618.5 ± 3.440.10 ± 0.01
B4.31 ± 0.771.00 (0.98-1.50)5.02 ± 1.6837.3 ± 12.90.12 ± 0.02
C5.24 ± 1.705.00 (3.00-9.10)8.32 ± 3.45115 ± 94.20.21 ± 0.09
D9.63 ± 1.8713.5 (12.0-24.0)25.3 ± 12.6490 ± 1390.49 ± 0.16
  • a Data are means ± SD, except for Tmax values, which are median (range) values.

  • b Each group included eight subjects.