TABLE 1.

Summary of demographic data by trial treatment

ParameterValue for group
A (CLCR, ≥80 ml/min)B (CLCR = 50-79 ml/min)C (CLCR = 30-49 ml/min)D (CLCR, <30 ml/min)
Total no. of subjects (n)8888
No. of males6553
No. of females2335
Mean (range) age (yr)39.1 (19-70)55.9 (21-73)56.8 (33-74)63.6 (49-72)
Mean (range) wt (kg)77.16 (66.0-90.0)72.9 (51.1-96.6)83.23 (62.9-107.0)89.84 (60.0-120.0)
Mean (range) height (cm)171.6 (162-179)166.6 (152-179)168.6 (157-180)167.8 (159-176)
Mean (range) BMI26.18 (22.8-30.8)26.06 (21.6-35.2)29.24 (24.4-37.0)31.75 (22.2-40.9)
Mean (range) CLCR (ml/min)121 (87.1-153)74.3 (65.2-82)46.9 (34.3-59)20.6 (16.4-25)