TABLE 4.

Independent risk factors for mortality in bloodstream infections caused by antimicrobial-resistant gram-negative bacilli based on multivariate analysisa

Risk factorAdjusted OR (95% CI)P value
All patients of study population (n = 286)
    High-risk source of bacteremia3.95 (1.66-9.41)0.002
    Presentation with septic shock40.99 (15.30-109.82)<0.001
    APACHE II score (per 1-point increment)1.29 (1.16-1.44)<0.001
    P. aeruginosa bacteremia3.07 (1.21-7.79)0.018
Patients with low-risk source of bacteremia (n = 154)b
    Presentation with septic shock23.01 (6.42-82.49)<0.001
    APACHE II score (per 1-point increment)1.25 (1.09-1.43)0.001
    P. aeruginosa bacteremia4.27 (1.33-13.67)0.015
Patients with high-risk source of bacteremia (n = 132)c
    Presentation with septic shock100.87 (17.98-565.89)<0.001
    APACHE II score (per 1-point increment)1.348 (1.13-1.61)0.001
    Inappropriate initial antimicrobial therapy3.64 (1.13-11.72)0.030
  • a Variables with a P value of <0.05 in the univariate analysis were candidates for multivariate analysis as well as the main variable of interest (i.e., inappropriate initial antimicrobial therapy).

  • b Multivariate analysis using a logistic regression model included the following variables: a long hospital stay, ICU care, neutropenia, polymicrobial, septic shock, APACHE II score, Pseudomonas infection, and inappropriate initial antimicrobial therapy.

  • c Multivariate analysis included ICU care, septic shock, APACHE II score, Pseudomonas infection, old age, and inappropriate initial antimicrobial therapy.