TABLE 4.

Urine pharmacokinetic parameters of tomopenem and its major metabolite following single-dose administration of 1,500 mg of tomopenem to subjects with various degrees of renal functiona

ParameterValue for group
ABCD
Tomopenem parameters
    CLR (liters/h)4.63 ± 0.893.68 ± 0.941.98 ± 0.770.59 ± 0.19
    Ae (mg)862 ± 79.01,090 ± 220939 ± 265618 ± 270
    Ae (% dose)57.4 ± 5.372.6 ± 14.762.6 ± 17.741.2 ± 18.0
RO4957463 parameters
    CLR (liters/h)13.2 ± 5.68.27 ± 2.93.91 ± 1.81.01 ± 0.5
    Ae (mg)240 ± 99.3279 ± 107281 ± 59.7194 ± 120
    Ae (% dose)16.0 ± 6.6218.6 ± 7.1318.7 ± 3.9813.1 ± 8.01
  • a Data are means ± SD (n = 8 for each group).