TABLE 1.

Demographic characteristics of study populationa

CharacteristicValue for groupbP value
Appropriate initial antibiotics (n = 135)Inappropriate initial antibiotics (n = 151)
No. of males83 (61.5)100 (66.2)NS
Age (yr) (mean ± SD, range)53 ± 16, 16-8656 ± 16, 16-95NS
APACHE II score (mean ± SD, range)11.39 ± 4.85, 0-2511.02 ± 5.15, 0-24NS
Underlying disease
    Leukemia20 (14.8)21 (13.9)NS
    Malignant lymphoma3 (2.2)4 (2.6)NS
    Solid organ transplantation7 (5.2)7 (4.6)NS
    Liver cirrhosis13 (9.6)14 (9.3)NS
    End-stage renal disease6 (4.4)6 (4.0)NS
    Pancreaticobiliary tract disease13 (9.6)20 (13.2)NS
    Solid tumor51 (37.8)59 (39.1)NS
    Others22 (16.3)20 (13.2)NS
Comorbid condition
    Neutropenia27 (20)29 (19.2)NS
    Presentation with septic shock33 (24.4)42 (27.8)NS
    Long hospital stay (> 14 days)79 (58.5)76 (50.3)NS
    ICU care27 (20)26 (17.2)NS
    Postoperative state19 (14.1)21 (13.9)NS
    Polymicrobial18 (13.3)25 (16.6)NS
Primary site of infection
    Catheter related3 (2.2)5 (3.3)NS
    Pancreaticobiliary tract50 (37)59 (39.1)NS
    Urinary tract14 (10.4)18 (11.9)NS
    Lung4 (3)12 (7.9)NS
    Peritoneum18 (13.3)21 (13.9)NS
    Unknown45 (33.3)32 (21.1)NS
Microorganism
    E. coli30 (22.2)31 (20.5)NS
    K. pneumoniae42 (31.1)23 (15.2)0.001
    Enterobacter species49 (36.3)37 (24.5)0.030
    P. aeruginosa14 (10.4)60 (39.7)<0.001
  • a NS, not significant (P > 0.05); SD, standard deviation.

  • b Number and percentage (in parentheses) of patients with each characteristic are shown.