TABLE 3.

Risk factors associated with 30-day mortality in bloodstream infections caused by antimicrobial-resistant gram-negative bacilli based on univariate analysis

Risk factorNo. of survivors (n = 191) (%)No. of nonsurvivors (n = 95) (%)OR (95% CI)P value
Inappropriate initial empirical antimicrobial therapy93 (48.7)58 (61.1)1.65 (1.001-2.73)0.049
Old age (>65 yrs)49 (25.7)28 (24.2)0.93 (0.52-1.64)0.791
Long hospital stay (>14 days)a87 (45.5)68 (71.6)3.01 (1.77-5.11)<0.001
Immunosuppressive therapy14 (7.3)16 (16.8)2.56 (1.19-5.50)0.013
Corticosteroid use30 (15.7)32 (33.7)2.73 (1.53-4.85)0.001
Care in ICU20 (10.5)33 (34.7)4.55 (2.43-8.52)<0.001
High-risk source of bacteremia62 (32.5)70 (73.7)5.83 (3.37-10.08)<0.001
Neutropenic state30 (15.7)26 (27.4)2.02 (1.11-3.67)0.019
Postoperative state24 (12.6)16 (16.8)1.41 (0.71-2.00)0.326
Polymicrobial23 (12)20 (21.1)1.95 (1.01-3.76)0.045
Presentation with septic shock10 (5.2)65 (68.4)39.22 (18.16-84.68)<0.001
APACHE II score
    ≤766 (34.6)6 (6.3)
    8-15109 (57.1)44 (46.3)<0.001
    ≥1616 (8.4)45 (47.4)
Microorganism
    E. coli48 (25.1)13 (13.7)0.47 (0.24-0.92)0.026
    K. pneumoniae44 (23)21 (22.1)0.95 (0.53-1.71)0.859
    Enterobacter species57 (29.8)29 (30.5)1.03 (0.61-1.77)0.906
    P. aeruginosa42 (22)32 (33.7)1.80 (1.04-3.11)0.033
  • a Hospital stay prior to onset of bacteremia.