TABLE 2.

MICs of β-lactams and non-β-lactamsa

DrugMIC (μg/ml) against indicated isolate (genotype)
K. pneumoniae clone A (blaOXA-48blaTEM-1blaSHV-12blaOXA-9)K. pneumoniae clone B (blaOXA-48blaTEM-1blaCTX-M-15blaOXA-1)E. coli J53(pAa) (blaCTX-M-15blaTEM-1blaOXA-1)E. coli J53(pAb) or -(pBb) (blaOXA-48)E. coli J53(pBa) (blaSHV-12blaTEM-1blaOXA-9)E. coli J53K. pneumoniae isolate 11 (blaOXA-48blaTEM-1blaOXA-1)K. pneumoniae isolate 21 (blaOXA-48blaTEM-1blaOXA-9)
Amoxicillin>512>512>512>512>5121>512>512
Amoxicillin + clavulanic acid>512>512>513>512>5121>512>512
Ticarcillin>512>512>514>512>5124>512>512
Ticarcillin + clavulanic acid>512>512>515>512>5124>512>512
Piperacillin>512>512>512>512>5124>512>512
Piperacillin + tazobactam>512>512>4-864>4-84>512>512
Cefotaxime>512>512>320,540.544
Ceftazidime>512>512128164122
Cefepime>512>5124<0.50.50.12544
Aztreonam>512>5128<0.125640.50.50.5
Cefoxitin16-51232->5122-44-82-4416>32
Moxalactam16->51216->512<0.52<0.51
Imipenem4-324-16<10.5<128-168-16
Meropenem>326-32<10.12<1<11616
Ertapenem>32>32<10.25<1<1>32>32
Kanamycin>256128
Tobramycin>64>64
Netilmicin>1283
Amikacin162
Gentamicin>641
Sulfamides>256>256
Trimethoprim>32>32
Tetracycline>256>256
Nalidixic acid>64>64
Norfloxacin8>256
Ofloxacin2>64
Ciprofloxacin1>128
  • a MICs are for K. pneumoniae isolates of clones A and B, E. coli J53 harboring natural plasmids pAa or pAb from clone A, E. coli J53 harboring natural plasmids pBa or pBb from clone B, K. pneumoniae isolates 11 and 21, and E. coli J53, as indicated.