TABLE 1.

MICs of quinolones for the E. coli clinical isolate R4525, its transconjugant, and reference strain E. coli J53 Azr

StrainaMutations in QRDRs:MICs (μg/ml) ofb:
gyrAparCNALNOROFLCIPENRSPX
E. coli R4525S83L + D87YS80I + E84G>256>256>32>32>32>32
Tc J53/R4525c32110.250.51
E. coli J53 Azr40.120.060.010.010.01
  • a Azr, azide resistance; Tc, transconjugant.

  • b NAL, nalidixic acid; NOR, norfloxacin; OFL, ofloxacin; CIP, ciprofloxacin; ENR, enrofloxacin; SPX, sparfloxacin.

  • c —, no mutation.