TABLE 2.

MAb 18B7 parameter estimates from noncompartmental PK analysis

Noncompartmental PK parameteraMedian valueRange (minimum, maximum)raP value
C max/dose (liter−1)0.120.032, 0.520.240.3309
T max (h)b41, 240.180.4664
t 1/2obs (h)5317, 214−0.510.0244
AUC/dose (h · liter−1)10.41.2, 31−0.0630.7973
CL (liter · h−1)0.0960.032, 0.850.0630.7973
V SS (liter)4.71.9, 41−0.100.6785
MRT (h)7321, 422−0.420.0700
  • a r, Spearman rank correlation versus dose.

  • b The mode was 2 h (6 of 19 patients).