TABLE 3.

Inhibitory effects of T-705 and ribavirin on cellular DNA and RNA synthesis

CompoundIC50 (μM)
[3H]thymidine[3H]uridine
T-705>637>637
Ribavirin2.1716.0
Aphidicolin<5NTa
Actinomycin DNT<5
  • a NT, not tested.