TABLE 2.

Reductions in bacterial load, pulmonary lesions, and loss of body weight in rats with pneumonia caused by one S. pneumoniae strain (AR09164) in relation to the time elapsed between challenge and initiation of amoxicillin treatment

ParameteraTime elapsed between bacterial challenge and treatment (time from challenge to necropsy) [no. of animals in untreated/treated group]
1 h (65 h) [6/6]24 h (88 h) [7/8]
Difference in log10 CFU/pair of lungs     compared to initial inoculum
    Untreated−0.48 ± 1.03b−1.11 ± 0.90b
    Treated−2.27 ± 1.09−2.43 ± 1.00
Extent of lung damage (%)
    Untreated53.96 ± 13.24c29.29 ± 6.92
    Treated21.25 ± 9.9721.70 ± 9.97
Relative lung weight (% of body     weight)
    Untreated1.63 ± 0.45c1.01 ± 0.26
    Treated0.97 ± 0.360.87 ± 0.15
Loss of body weight (%)
    Untreated11.80 ± 3.999.78 ± 3.84
    Treated7.54 ± 4.027.33 ± 4.10
  • a Values are means ± SD.

  • b Values for untreated and treated groups are significantly different (P < 0.02).

  • c Values for untreated and treated groups are significantly different (P < 0.05).