TABLE 1.

Pulmonary lesions and loss of body weight in rats with pneumonia caused by four S. pneumoniae strains and treated with simulated human treatment-like slow-release amoxicillin therapy

ParameteraPneumococcal strain (amoxicillin MIC, μg/ml) [no. of animals in untreated/treated group]
AR30118 (≤0.015) [6/8]FJD70 (2) [6/6]AR06016 (4) [10/10]AR09164 (4) [9/11]
Extent of lung damage (%)
    Untreated49.17 ± 27.18b42.92 ± 22.58b49.37 ± 20.93b38.89 ± 12.80b
    Treated10.47 ± 5.8218.33 ± 6.7421.00 ± 8.7015.11 ± 14.16
Relative lung weight (% of body weight)
    Untreated2.02 ± 0.97b1.51 ± 0.65b1.55 ± 0.73b1.45 ± 0.40b
    Treated0.85 ± 0.100.77 ± 0.181.00 ± 0.300.92 ± 0.25
Loss of body weight (%)
    Untreated13.90 ± 4.92b8.29 ± 4.0410.59 ± 6.1813.10 ± 4.25b
    Treated4.87 ± 2.625.10 ± 2.568.25 ± 4.787.34 ± 6.00
  • a Values are means ± SD.

  • b Values for untreated versus treated groups are significantly different (P < 0.05).