TABLE 1

MIC determinations against wild-type M. tuberculosis H37Rv and cyd mutant strains

CompoundM. tuberculosis straina
H37RvcydKO (cydC::aph) mutant strainΔcydA mutant strainΔcydAB mutant strain
Rifampin0.010.010.010.01
Isoniazid0.040.040.040.04
Streptomycin0.90.90.90.9
Ethambutol0.470.470.470.47
Pretomanid (PA-824)0.10.10.10.1
Levofloxacin0.940.940.940.94
BDQ0.030.03–0.060.030.03–0.06
Q2030.0097 (>50)c0.00030.00120.0003
Compound 1b3.125 (>50)c0.390.390.39
Compound 2b0.390 (>25)c0.020.04880.02
  • a All values are 14-day MABA (19) MIC90s and are reported in micrograms per milliliter.

  • b Compound numbers are as per reference 13.

  • c The MIC was determined visually according to the presence/absence of a definite mycobacterial pellet.