TABLE 4.

Mean pharmacokinetic parameters for plasma micafungin concentrations at days 1 and 7 of dosing by dose group

Daily dose (mg)No. of patientsStudy dayCmax (μg/ml)AUC0-24 (h · μg/ml)AUC0-∞ (h · μg/ml)t1/2 (h)CL (liters/h)Vss (liters)
12.5810.99.011.611.31.0917.7
871.111.916.711.51.1116.4
25911.616.624.214.61.1423.1
874.123.834.912.41.0516.4
50913.633.944.612.51.2021.7
974.444.364.012.21.0618.0
75915.447.064.312.71.2621.8
878.363.091.113.41.4723.7
100917.159.981.113.01.2523.0
8722.0101.6126.212.01.0817.3
15010111.7103.6144.613.01.1221.0
8717.6166.7230.312.90.9816.7
2008113.1118.1164.314.31.2825.6
8722.6210.6438.020.10.9623.4