TABLE 3.

Mean laboratory values at baseline and end of therapy by treatment group

Lab parameterVisitaMean value (SD) for indicated group
Control (n = 12)b12.5 mg (n = 8)25 mg (n = 9)50 mg (n = 9)75 mg (n = 9)100 mg (n = 9)150 mg (n = 10)200 mg (n = 8)
Creatinine (mg/dl)Baseline0.69 (0.21)0.78 (0.51)0.68 (0.14)0.63 (0.17)0.76 (0.35)0.66 (0.17)0.75 (0.15)0.73 (0.44)
EOT0.68 (0.21)0.89 (0.73)0.70 (0.25)0.79 (0.39)0.72 (0.16)0.64 (0.13)0.74 (0.20)0.89 (0.29)
AST (U/liter)Baseline35.9 (21.4)28.0 (13.2)27.6 (20.4)46.3 (39.1)33.9 (33.1)43.6 (18.8)37.8 (15.7)33.0 (24.5)
EOT15.3 (5.2)19.1 (11.0)14.9 (5.8)18.6 (8.9)15.9 (7.2)19.4 (7.9)28.7 (14.9)21.0 (10.2)
ALT (U/liter)Baseline44.1 (27.4)31.0 (19.9)26.3 (7.2)63.1 (52.4)46.4 (34.7)38.8 (20.8)53.4 (28.6)44.6 (39.5)
EOT23.3 (12.7)23.9 (11.1)24.1 (25.2)35.8 (26.2)17.6 (8.0)30.3 (34.5)38.9 (31.8)32.4 (28.1)
Total bilirubin (mg/dl)Baseline0.63 (0.22)0.60 (0.29)0.71 (0.33)0.86 (0.87)0.93 0.600.73 (0.28)0.84 (0.72)0.68 (0.42)
EOT0.70 (0.26)0.64 (0.52)0.80 (0.38)1.63 (1.75)1.02 (0.61)0.89 (0.59)0.92 (0.33)1.16 (0.53)
  • a EOT, end of therapy.

  • b n, no. of subjects.