TABLE 2.

In vitro activities of daptomycin alone and in combination with gentamicin or rifampin

IsolateMIC of daptomycin (mg/liter)Drug(s) and doseaT99b (h)RegrowthcFold change in MIC of daptomycin
CB 18150.25D66.9 ± 0.2Y3
D6 + G4.6 ± 0.3N0
D6 + R40.6 ± 2.0N0
D103.8 ± 0.2N0
D10 + G10.2 ± 0.5N0
D10 + R29.5 ± 2.3N0
CB 18132D6NAY1.5
D6 + GNAY0
D6 + RNAN0
D10NAN0
D10 + G16.8 ± 0.7N0
D10 + R50.9 ± 5.1N0
CB 18144D6NAY1.5
D6 + GNAY0
D6 + RNAN0
D10NAY0
D10 + GNAY0
D10 + R49.8 ± 1.4N0
CB 17340.25D66.6 ± 0.3N0
D6 + G3.0 ± 0.2N0
D6 + R48.1 ± 1.2N0
D102.0 ± 1.4N0
D10 + G1.8 ± 0.1N0
D10 + R7.4 ± 0.3N0
CB 17352D68.3 ± 0.4Y2
D6 + G7.7 ± 0.3N0
D6 + R59.7 ± 4.1N0
D103.0 ± 0.1N0
D10 + G3.8 ± 0.2N0
D10 + R60.8 ± 5.6N0
CB 17400.25D618.9 ± 6.6N0
D6 + G2.6 ± 0.2N0
D6 + R37.9 ± 4.7N0
D109.7 ± 0.6Y0
D10 + G5.4 ± 0.2N0
D10 + R8.9 ± 1.2N0
CB 17412D6NAY0
D6 + GNAY0
D6 + R61.7 ± 5.2N0
D1030.8 ± 2.4N0
D10 + GNAN0
D10 + R88.1 ± 5.9N0
  • a D6, daptomycin at 6 mg/kg/day; D10, daptomycin at 10 mg/kg/day; G, gentamicin at 5 mg/kg daily; R, rifampin at 300 mg every 8 h.

  • b NA, not achieved; T99, time to achieve a 99.9% bacterial load reduction.

  • c Y, yes; N, no.