TABLE 2.

Relationship of MIC to mortality in patients with candidemia

MIC (μg/ml) by susceptibility levelaMortality at the indicated MIC (no. of nonsurvivors/total no. in group [%])b
MIC2450MIC2480MIC4850MIC4880
Susceptible
    0.1255/20 (25)2/5 (40)3/9 (33.3)1/3 (33.3)
    0.254/21 (19)3/20 (15)3/18 (16.7)2/12 (16.7)
    0.56/15 (40)5/21 (23.8)5/22 (22.7)5/26 (31)
    10/1 (0)5/11 (45.5)1/4 (25)2/9 (22.2)
    22/8 (25)1/1 (100)0/2 (0)2/2 (50)
    43/8 (37.5)1/12 (8.3)3/11 (27.3)1/9 (11.1)
    80/1 (0)3/4 (75)3/5 (60)4/6 (66.7)
    Total20/74 (27)20/74 (27)18/71 (25)17/69 (24.6)
S-DD
    16000/1 (0)1/3 (33.3)
    320/3 (0)0/2 (0)0/2 (0)0/2 (0)
    Total0/3 (0)0/2 (0)0/3 (0)
Resistant (64)4/7 (57.1)4/8 (50)6/10 (60)6/10 (60)
  • a Susceptible, MIC of ≤8 μg/ml; S-DD, MIC of 16 to 32 μg/ml; resistant, MIC of ≥64 μg/ml.

  • b MICs were read visually after 24 h or 48 h of incubation and determined at 50% or 80% inhibition (MIC2450, MIC2480, MIC4850, and MIC4880, respectively) compared with growth control. Eighty-four patient isolates were included.