TABLE 1.

Pharmacokinetic parameters of daptomycin, gentamicin, and rifampin achieved using in vitro pharmacodynamic model with the SEVsa

Drug, dosageCmax (mg/liter)Cmin (mg/liter)Half-life (h)AUC0-24 (mg/liter·h)
Daptomycin, 6 mg/kg/day103.0 ± 7.619.4 ± 2.68.9 ± 1.91504.6 ± 149.9
Daptomycin, 10 mg/kg/day162.3 ± 3.419.0 ± 8.57.8 ± 1.91736.8 ± 111.0
Gentamicin, 5 mg/kg/day16.6 ± 0.60.04 ± 0.02c2.8 ± 0.360.8 ± 4.0
Rifampin, 300 mg q8hb6.2 ± 0.81.3 ± 0.33.2 ± 0.5107.7 ± 6.0
  • a C max, maximum concentration; Cmin, minimum concentration; AUC0-24, area under the concentration-time curve from 0 to 24 h. Results are expressed as means ± standard deviations.

  • b q8h, every 8 h.

  • c Extrapolated data; limit of detection = 0.27.