TABLE 5

Effects of 24-h daptomycin exposure on isolate susceptibility

Drug testedIncubation with daptomycinMIC50/MIC90 (μg/ml)aNo. susceptible/total no. (%)bNo. nonsusceptible/total no. (%)b
MIC50 at 24 hMIC90 at 24 hMIC50 at 48 hMIC90 at 48 h
DaptomycinPreincubation0.0940.125NPNP48/50 (96)2/50 (4)
Postincubation>256>256NPNP0/50 (0)50/50 (100)
VancomycinPreincubation0.250.380.380.5050/50 (100)0/50 (0)
Postincubation0.380.500.500.7550/50 (100)0/50 (0)
TelavancinPreincubation0.0120.0160.0160.023NANA
Postincubation0.0120.0160.0120.016NANA
  • a NP, not performed.

  • b Based on CLSI M45, 3rd edition (26). NA, no interpretative data available.