TABLE 1.

Influence of qnrA and its homologue, VPA0095 from V. parahaemolyticus, on the drug susceptibilities of E. coli

PlasmidGene carriedbChange in MIC (n-fold) for E. coli strain KL16a
Cipro- floxacinLevo- floxacinNalidixic acidMino- cycline
pTV118N (vector)1 (0.015)1 (0.03)1 (4)1 (1)
pKPQNR qnrA 161641
pVPQNR8VPA0095(TGT)1-211-21
pVPQNR2VPA0095(TAT)16168-161
pVPQNR8C115YcVPA0095(TAT)16168-161
pVPQNR2Y115CdVPA0095(TGT)21-21-21
  • a The change is the ratio of the MIC for the strain with the indicated plasmid to the MIC, shown in parentheses, for the strain with pTV118N.

  • b The 115th codon is shown in parentheses.

  • c Acquired from pVPQNR8 by site-directed mutagenesis.

  • d Acquired from pVPQNR2 by site-directed mutagenesis.