TABLE 1.

Symptoms related to administration of cαStx2 in healthy adult volunteers

SymptomNo. with symptom/total no. volunteersTotal
0.1 mg/kg1 mg/kg3 mg/kg10 mg/kg
Headache1/32/33/83/39/17
Fatigue1/31/33/80/35/17
Rash0/31/30/80/31/17
Metallic taste0/30/31/80/31/17
Joint pain0/30/30/82/32/17
Dizziness0/30/30/81/31/17
Hypotension0/30/32/8a0/32/17
Leukopenia or anemia0/30/30/81/31/17
Elevated AST and/or ALT1/30/32/80/33/17
  • a In these two volunteers, the infusion was stopped after administration of approximately half the dose due to asymptomatic hypotension; this was a requirement of the clinical protocol.