TABLE 3.

MICs of β-lactams for the PER-1-producing P. aeruginosa RNL-1, MUL-2, 1, PER12, and 2622 clinical isolates; the PER-1-producing A. baumannii AMA-1 and C.A. clinical isolates; the S. enterica serovar Typhimurium TUR and 147 clinical isolates; the E. coli DH10B strain harboring natural plasmid pSTI1 from S. enterica serovar Typhimurium 147 expressing PER-1; and the E. coli DH10B reference strain

β-Lactam(s)aMIC (μg/ml)
P. aeruginosa RNL-1P. aeruginosa MUL-2P. aeruginosa 1P. aeruginosa PER 12P. aeruginosa 2622A. baumannii AMA-1A. baumannii C.A.P. stuartii BENS. enterica serovar Typhimurium TURS. enterica serovar Typhimurium 147E. coli DH10B (pST11)E. coli DH10B
Amoxicillin>512>512>512>512>512>512>512>512>512>5124
Amoxicillin + CLA>512>512>512>512>512328512323224
Ticarcillin512>512512>512512>512>512512>512>5125124
Ticarcillin + CLA256128512>512128128256161286414
Piperacillin8161664166451216256256161
Piperacillin + TZB8161664166425616646421
Cefuroxime>512>512>512>512>512>5125122565125125122
Ceftazidime256512128512512>5125125125125125120.06
Cefotaxime256>512256>512>512>512>512322565121280.12
Cefepime32641651232512512212825680.06
Aztreonam256512256512512512>512161282565120.12
Imipenem10.53264320.50.2520.120.250.120.06
  • a CLA, clavulanic acid at a fixed concentration of 2 μg/ml; TZB, tazobactam at a fixed concentration of 4 μg/ml.