TABLE 2.

Individual pharmacokinetic parameters obtained with single-dose intravenous cαStx2

SubjectDose (mg/kg)Cmax (mg/liter)Tmax (h)AUC0-∞ (mg · h/liter)CL (ml/kg/h)t1/2 (h)V (liter/kg)
1000-050.12.41.51590.63049.20.0447
1000-070.12.21.252040.49067.30.0476
1000-080.12.61.02000.50152.10.0376
Mean (SD)2.4 (0.2)1.25 (0.25)188 (25.0)0.540 (0.08)56.2 (9.7)0.043 (0.005)
1000-111322.0**a******
1000-12120.41.53,8830.258187.30.0696
1000-01123.13.03,7580.266150.70.0578
Mean (SD)25.2 (6.1)2.2 (0.8)********
1000-13372.91.511,4710.262169.00.0638
1000-10391.62.013,4380.223169.00.0545
1000-18367.61.2510,7860.278203.80.0818
1000-253109.95.012,9160.232141.40.0474
1000-26359.41.511,5650.259247.50.0926
1000-28358.73.012,0050.250247.50.0892
Mean (SD)76.7 (20.2)2.4 (1.4)12,030 (984)0.251 (0.02)196.4 (44.3)0.072 (0.019)
1000-1910189.41.2542,0000.238216.60.0744
1000-2110254.51.549,7870.201192.50.0558
1000-2010201.91.2537,1100.269210.00.0817
Mean (SD)215.3 (34.5)1.3 (0.1)42,966 (6393)0.236 (0.034)206.4 (12.4)0.071 (0.013)
  • a **, unable to determine.