TABLE 2.

Summary of the pharmacokinetic parameters of oseltamivir in plasma and CSF by ethnic group and total populationa

Group (n)Cmax (ng/ml)Tmax (h)Clast (ng/ml)Tlast (h)AUC0-last (h·ng/ml)t1/2 (h)AUC0- (h·ng/ml)CL/F (liters/h)CSF/plasma ratio (%)
PlasmaCSFPlasmaCSFPlasmaCSFPlasmaCSFPlasmaCSFPlasmaCSFPlasmaCSFPlasmaCSFCmaxAUC0-last
Caucasian (4)100 ± 39.62.1 ± 0.52.0 (0.5-4.0)4.0 (2.0-5.0)1.9 ± 0.51.3 ± 0.312.0 (9.0-12.0)7.5 (5.0-9.0)299 ± 62.89.4 ± 4.61.8 ± 0.2NCb304 ± 64.0NC512 ± 118NC2.3 ± 0.53.0 ± 1.0
Japanese (4)130 ± 39.82.6 ± 1.31.0 (0.5-1.0)3.0 (1.0-5.0)2.3 ± 0.91.4 ± 0.39.0 (9.0-12.0)4.0 (2.0-8.0)317 ± 92.35.9 ± 4.01.7 ± 0.4NC323 ± 93.6NC492 ± 126NC1.9 ± 0.51.7 ± 0.8
Total (8)115 ± 40.02.4 ± 0.91.0 (0.5-4.0)3.5 (1.0-4.0)2.1 ± 0.71.4 ± 0.310.5 (9.0-12.0)5.5 (2.0-9.0)308 ± 73.77.6 ± 4.41.8 ± 0.3NC313 ± 74.9NC502 ± 113NC2.1 ± 0.52.4 ± 1.1
  • a Values are arithmetic means (± SDs) apart from Tmax and Tlast, which are medians (range). Values are reported with three significant figures and/or a maximum of one decimal place.

  • b NC, not calculated.