TABLE 1.

Translation-inhibitory activities of Rχ-01 compounds

CompoundIC50 (μM) of source of ribosomes for translationSelectivity ratioa
S. aureus QC ATCC 29213S. aureus A7820 (Linr Ermr)
Rx-01_0020.090.0317
Rx-01_007≤0.02≤0.02>100
Rx-01_133≤0.02≤0.02>50
Rx-01_149≤0.020.08>100
Rx-01_4130.130.21>100
Rx-01_423≤0.020.06>100
Rx-01_4450.060.0623
Rx-01_6670.020.03>100
Linezolid0.98.4>100
Chloramphenicol7.85425
Florfenicol0.716.4>100
Sparsomycin≤0.02≤0.027
  • a Rabbit reticulocyte IC50/S. aureus QC IC50.