TABLE 3.

Summary of the pharmacokinetic parameters of OC in plasma and CSF by ethnic group and total populationa

Group (n)Cmax (ng/ml)Tmax (h)Clast (ng/ml)Tlast (h)AUC0-last (h·ng/ml)t1/2 (h)AUC0- (h·ng/ml)CSF/plasma ratio (%)
PlasmaCSFPlasmaCSFPlasmaCSFPlasmaCSFPlasmaCSFPlasmaCSFPlasmaCSFCmaxAUC0-last
Caucasianb (4)507 ± 11717.7 ± 19.75.5 (4.0-6.0)8.0 (7.0-12.0)56.4 ± 9.812.0 ± 1.324.0 (24.0-24.0)12.0 (12.0-24.0)5,380 ± 1,180185 ± 2975.9 ± 0.4NCc5,860 ± 1,210NC3.5 ± 4.23.6 ± 6.0
Japanese (4)581 ± 50.520.4 ± 11.34.5 (4.0-6.0)7.5 (6.0-12.0)44.0 ± 19.416.3 ± 7.324.0 (24.0-24.0)12.0 (12.0-12.0)5,700 ± 826129 ± 67.65.0 ± 0.9NC6,030 ± 1,000NC3.5 ± 1.72.3 ± 1.1
Total (8)544 ± 92.619.0 ± 14.95.0 (4.0-6.0)8.0 (6.0-12.0)50.2 ± 15.714.5 ± 5.724.0 (24.0-24.0)12.0 (12.0-24.0)5,540 ± 957157 ± 2025.4 ± 0.8NC5,950 ± 1,030NC3.5 ± 2.92.9 ± 4.1
  • a Values are arithmetic means(± SDs) apart from Tmax and Tlast, which are medians (ranges). Values are reported with three significant figures and/or a maximum of one decimal place.

  • b For one Caucasian subject, all CSF metabolite concentrations were below quantifiable limits and were interpreted as 0 ng/ml; pharmacokinetic parameters for OC in CSF were not calculated, but Cmax and AUC0-last values of 0 were included in the respective summary statistics for these parameters and were used to calculate the respective CSF/plasma ratios of 0.

  • c NC, not calculated.