TABLE 1.

Experimental design for drug-drug interactions study (experiment I)

Treatment groupaTotal no. of miceNo. of mice killed on:
D−13D0W2W4W6W8
Control3061266
RHZ246666
RHZJ3246666
RHZJ6.25246666
RHZJ12.5246666
RHZJ25246666
  • a The dosages were as follows: INH, 25 mg/kg; RIF, 10 mg/kg; PZA, 150 mg/kg; R207910, 3, 6.25, 12.5, or 25 mg/kg.