TABLE 1.

Characteristics of unique patients with E. faecalis and E. faecium bacteremia pre- and postimplementation of the PNA FISH test

CharacteristicaValue
E. faecalisE. faecium
Pre-PNA FISH (n = 64)PNA FISH (n = 48)PPre-PNA FISH (n = 65)PNA FISH (n = 47)P
Age [median yr (range)]53 (18-90)60 (19-78)0.254 (22-83)53 (21-84)0.5
Male sex [no. (%)]29 (45)29 (60)0.1137 (57)23 (49)0.4
ICU at BC draw [no. (%)]28 (44)19 (40)0.6633 (51)20 (41)0.39
Neutropenic at BC draw [no. (%)]6 (9)2 (4)0.2913 (20)17 (36)0.06
Central line at BC draw [no. (%)]57 (89)44 (92)0.6559 (91)43 (91)0.9
Median LOS until BC draw (days) [median (range)]5 (0-64)2 (0-101)0.6812 (0-99)14 (0-123)0.72
LOS from BC to discharge (days) [median (range)]9 (2-50)10 (1-60)0.30413 (1-85)14 (1-175)0.44
Median WCC at BC draw (103 cells/dl) [median (range)]10.8 (0.1-38.3)8.7 (1-47.3)0.99.2 (0.1-40.5)5.7 (0.1-31.7)0.04b
Median APACHE II score at BC draw [median (range)]12 (3-28)14 (5-28)0.0816 (5-25)16 (5-23)0.9
Ampicillin susceptible [no. (%)]64 (100)48 (100)10 (0)0 (0)1
Vancomycin susceptible [no. (%)]57 (89)43 (90)0.9311 (17)2 (4)0.04b
Other bacteria in same BC draw [no. (%)]41 (64)30 (63)0.8722 (34)15 (34)0.9
Total time in days from BC drawn to final microbiological report [median (range)]4 (2.4-9.8)4.1 (2.3-8.5)0.333.3 (2.0-8.6)3.4 (2.5-7.1)0.91
Total time in days from BC drawn to PNA FISH report1.1 (0.5-3.3)<0.001b1.1 (0.5-3.5)<0.001b
Total time in days from BC drawn to appropriate therapy [median (range)]0 (0-5.3)0.3 (0-6.5)13.1 (0-9)1.3 (0-4.3)<0.001b
Initial appropriate empirical therapy [no. (%)]63 (98)46 (96)0.412 (18)6 (13)0.42
Received appropriate therapy after final microbiological report [no. (%)]64 (100)48 (100)156 (86)46 (98)0.04b
30 day mortality [no. (%)]8 (13)5 (10)0.7329 (45)12 (26)0.039b
  • a BC, blood culture; LOS, length of stay; WCC, white cell count.

  • b Significant value.