TABLE 1.

Pharmacokinetic parameters of micafungin in nonneutropenic rabbits with HCME from the population analysis after multiple daily doses over 6 daysa

Dosage (mg/kg)Vc (liters)Kcp (h−1)Kpc (h−1)SCL (liters/h)AUC0-∞ (μg/ml·h)
0.50.535 (0.064)0.542 (0.135)0.281 (0.046)0.129 (0.012)10.75 (0.589)
20.450 (0.088)0.664 (0.430)0.350 (0.320)0.113 (0.016)49.55 (7.88)
40.633 (0.136)0.484 (0.182)0.514 (0.124)0.144 (0.029)77.83 (20.24)
80.649 (0.153)0.743 (0.933)0.587 (0.364)0.175 (0.049)137.22 (30.05)
160.659 (0.122)0.666 (0.743)0.622 (0.286)0.158 (0.010)305.71 (24.96)
240.611 (0.377)0.852 (1.013)0.617 (0.299)0.146 (0.084)767.33 (466.23)
320.577 (0.165)0.537 (0.304)0.509 (0.349)0.141(0.032)788.5 (230.83)
Overall model0.588 (0.185)0.612 (0.739)0.454 (0.361)0.143 (0.041)
  • a All values are expressed as means, and standard deviations are shown in parentheses. Vc, volume of the central compartment; SCL, clearance; Kcp and Kpc, first-order intercompartmental rate constants; AUC0-∞, area under the plasma concentration-time curve from time zero to infinity.