Survival and MTD of N. fowleri-infected mice treated with various drugs

GroupaNo. of miceNo. of surviving miceb (%)MTDc (days)
Amphotericin B208 (40)17.3
Miltefosine2011 (55)19.3
Chlorpromazine2015 (75)17.2
Controld200 (0)11.2
  • a All groups were treated with drugs three times at days 3, 7, and 11, respectively. The control group received 100 μl of saline under the same conditions.

  • b Mice were held for 28 days after inoculation, and the cumulative percentage was recorded on a daily basis.

  • c The MTD was calculated based only on dead mice.