TABLE 1.

Susceptibility to terbinafine of S. cerevisiae strain INVSc1 transformed with three different variants of the C. albicans SE gene cloned into the galactose-inducible expression vector pYES2a

ConstructNucleotide mutationAmino acid mutation50% MIC90% MIC
None18
pYES20.54-8
CaSENone (wt seqb)S172L18
CaSE514CTG→TCTNone18
CaSE1191TTA→TTCL398F>128>128
  • a 50% MIC and 90% MIC correspond to the lowest terbinafine concentrations (μg/ml) leading to reductions of growth of ≥50% and ≥90%, respectively, in comparison with controls.

  • b wt seq, wild-type sequence.