TABLE 3.

Amino acid mutations PBP 3 from the 36 clinical isolates

ClassTotal no. of isolatesNo. of strains with the following amino acid mutationa:
S7PA22TQ28KP31SV34LC56GA60TN75SN122HL124IA125VA131SE135QE141KS152AL165SS166NN169DR173KI180NL219I/MT228IA239ES242AA271VS273AE274DG280AD350NS357NM377IS385TL389FA437ST443A/SI449VG490EA502V/TV511AR517HI519LN526KA530ST532SV547ID551N/Y/VG555EY557HV562LN569SA586SS594TA595TI601LE603D/G
I1236431413144244430/419197113/6 12 1190/1/179888/0
II43111122221310/314111441 4 10/12/022 4 2421111/1
III1115511211111111 11 11 11 1111113333/0
IV511211111112112/05113122/0 5 31/0/011323323/1
V3122222320/23332 3 1/0 3 231133333/0
VI1110/11111 1 1 1 1 111111/0
  • a Mutations are in reference to the PBP3 sequence of the Rd strain. The amino acid substitutions used for classification are set in boldface type.